Every stage of the cycle already has a good product selling it. This page puts them beside Essential™ — what each does well, what the five cost together for 28 days, and how many doses sit at a dose a human trial actually used.
Essential™ is the one formula that ships all five.
| Product | Stage | What it does well |
|---|---|---|
| Tru Niagen | Build | Multiple human RCTs on nicotinamide riboside |
| Elysium | Build | Published trials, named scientists |
| Renue by Science | Build | The widest NAD+ range and formats; fewer published endpoints |
| MitoQ | Protect | Mitochondria-targeted delivery, demonstrated in humans |
| Timeline / Mitopure | One step of Clear | 25 human trials over 18 years on urolithin A8 — the deepest record in the table |
| Nootropics Depot | Signal | Per-batch assays published; erinacine A stated by name on the label4 |
| Qualia Mitochondria+ | Build, Protect, part of Clear | An in-house research programme; 11 of 33 actives at a studied dose9 |
| Essential™ | Signal, Build, Fuel, Protect, Clear | Every dose published next to its human study; all 19 at or above the studied dose |
Essential™ is $199 for 28 days of all five stages — one mug. Every row above is that same 28 days at our doses, priced from each label's own serving size10. See the price →
Not a price comparison — a dose-discipline one: how much of what you buy sits at a dose a human trial used. Both figures count the doses each label publishes, ours from the Evidence page, theirs from their own panel.
The four leading mushroom coffees carry a gram or two of mushroom per serving; one discloses per-mushroom amounts, and none names a standardised active17. Essential™'s five mushrooms come to 5,000 mg, each amount and each active on the label5. The rest of the formula is drawn faint, for scale. At $7.11 a mug the difference you are buying is what's disclosed, and the four stages beyond the mushrooms.
Per-serving amounts as disclosed on each label17. Ryze's MCT and prebiotic fibre and MUD\WTR's cacao and spices carry no disclosed amounts, so they cannot be drawn. MUD\WTR’s 2,240 mg is mushrooms and mycelium grown on oat or sorghum, per their own label — grain substrate included. Which of Essential™'s doses sit at or above their studied dose is on the Evidence page.